Hevylite可以使您的實(shí)驗(yàn)室受益，因?yàn)樗梢裕?/span>
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提供比電泳方法更高的靈敏度
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克服了電泳觀察到的技術(shù)難題，例如共遷移，非線性和染料飽和
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通過自動(dòng)化*大化工作流程并減少“動(dòng)手”時(shí)間
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提供定量結(jié)果并避免主觀理解凝膠
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減少獲得結(jié)果所需的不同測(cè)試的次數(shù)，尤其是對(duì)于IgA單克隆蛋白
Hevylite allows improved monitoring of Multiple Myeloma patients by more accurate measurement of intact immunoglobulin monoclonal proteins. It is a set of unique laboratory serum tests which overcome some of the problems found using electrophoretic methods, especially when monitoring IgA Multiple Myeloma.
“The HLC assays allow new ways to examine plasma cell biology and disease. We are able to identify abnormalities that were previously hidden from our view…”
Katzmann et al. Leukemia 2013;27:1-2
Hevylite is a simple, polyclonal antibody serum test for intact immunoglobulin monoclonal gammopathies including Multiple Myeloma. It can:
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Accurately quantify monoclonal proteins when SPE and IFE bands are difficult to interpret
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Accurately quantify monoclonal proteins at low levels (<10 g/L)
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Identify residual disease in Multiple Myeloma
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Detect Multiple Myeloma relapse earlier than traditional testing
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Provide optimal monitoring alongside Freelite
The test provides rapid accurate results that play an important role in:
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Diagnosis - provides Hevylite a baseline value that is useful in monitoring and prognosis
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Prognosis - to predict patient outcomes
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Monitoring - to measure response to treatment
Hevylite is a quick, simple and highly sensitive laboratory serum test for measuring intact immunoglobulin monoclonal proteins. It identifies and measures IgGκ, IgGλ, IgAκ, IgAλ, IgMκ and IgMλ individually. These proteins are assessed in pairs, e.g. IgGκ/IgGλ, to produce ratios.
Traditional blood tests for monoclonal gammopathies are serum protein electrophoresis (SPE or SPEP) with scanning densitometry, CZE (capillary zone electrophoresis) and/or immunofixation electrophoresis (IFE) together with serum free light chain immunoassays.
Hevylite can benefit your lab because it:
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provides greater sensitivity than electrophoretic methods
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overcomes technical challenges observed with electrophoresis such as co-migration, non-linearity and dye saturation
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maximizes workflow through automation and reduces “hands-on” time
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provides quantitative results and avoids subjective interpretation of gels
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reduces the number of different tests needed to get a result, especially for IgA monoclonal proteins
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